Laryngeal amyloidosis: a single-centre four-patient case series highlighting diagnostic challenges and clinical...

Laryngeal amyloidosis is a rare condition that may mimic benign, malignant or functional laryngeal disorders. We present a single-centre four-patient case series demonstrating clinical heterogeneity in anatomical distribution, amyloid typing, systemic association and management. All four cases were confirmed histologically. Two patients had localized AL laryngeal amyloidosis following specialist assessment, one patient had laryngotracheal amyloid deposition in the context of known multiple myeloma, and one patient had untyped laryngeal amyloidosis involving the bilateral ventricles and vocal cords. Management varied from conservative airway surveillance to endoscopic debridement, guided by symptom burden, anatomical extent, airway risk and systemic context. This series highlights that the value of reporting multiple cases lies not only in rarity, but in comparing consistent diagnostic principles with divergent disease behaviour and treatment pathways.