A platinum nanozyme integrated with gelatin methacryloyl microneedles for diabetic wound healing

Diabetic wounds are persistently exposed to pathological microenvironments, such as hyperglycemia and excessive ROS accumulation, which result in insufficient angiogenesis and restricted cell migration, representing a prominent challenge in clinical wound repair. Traditional wound dressings primarily focus on passive coverage and exudate absorption, making it difficult to actively regulate the microenvironment of diabetic wounds. Therefore, in this study, platinum nanozyme (PtNP)-loaded methacrylated gelatin (GelMA) microneedles (Pt-GelMA microneedles) were constructed, aiming to synergistically accelerate diabetic wound healing by leveraging the local penetration and delivery capacity of microneedles and the hydrogen peroxide decomposition capacity of PtNPs. In vitro assays demonstrated that the Pt-GelMA microneedles have favorable cytocompatibility and can alleviate oxidative stress, promote the migration of wound repair related cells and enhance the tube formation of endothelial cells. Furthermore, in a streptozotocin-induced diabetic full-thickness skin wound model, the Pt-GelMA microneedles significantly accelerated wound closure, and promoted collagen deposition and angiogenesis, without inducing evident hepatorenal toxicity. This study provides new insights into the treatment of diabetic wounds.