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Updated: Sep 30, 2026

Intravenous Endotoxin Challenge in Healthy Humans: An Experimental Platform to Investigate and Modulate Systemic Inflammation
Published on: May 16, 2016
[Inflammation: effective response or vulnerability related to sex?]
1Secrétaire perpétuel de l'Académie royale de médecine de Belgique.
Abstract:
Life expectancy is sex-dependent: women live longer than men, and even though it is improving in both sexes, this difference remains true.The recent Covid-19 crisis has been pathognomonic of this. The essential element of this dimorphism is the way in which each sex controls inflammatory homeostasis, both in terms of kinetics and intensity. This review evaluates the mechanistic literature on the subject, the diagnostic, regulatory, and therapeutic aspects; it concludes with future prospects for the management of patients with severe infections or other concerning inflammatory disorders.
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