Related Experiment Video
Updated: Sep 30, 2026
Optimizing Extracellular Vesicle Delivery Using a Core-Sheath 3D-Bioprinted Scaffold for Chronic Wound Management
Published on: February 28, 2025
A dual-action biotin nanogel for accelerated wound healing: a bioinspired approach to antioxidant and regenerative
Samaa Abdullah1,2, Samar Thiab1, Alaa A Al-Masud3,4
1Faculty of Pharmacy, Applied Science Private University, Amman 11937, Jordan.
Abstract:
A biotin-coenzyme Q10-sodium alginate (BTN-CoQ10-SA) nanogel was developed for topical wound healing through combined antioxidant and regenerative delivery. The optimized nanogel showed a particle size of ∼115 nm, zeta potential of -35.1 mV, encapsulation efficiency of 88.3%, and sustained BTN release over 24 h. In a rat excisional wound model, the nanogel achieved 95.1% wound closure by day 14 and significantly outperformed the untreated control. Treatment also increased VEGF, collagen I, and TGF-β1 expression while reducing IL-6 levels. These findings demonstrate the potential of BTN-CoQ10-SA nanogels as a sustained topical system for promoting wound repair.
Related Concept Videos
01:19Clinical Applications of Epidermal Stem Cells
01:19Overview of Regeneration and Repair
Regeneration
All animals have varying degrees of...
01:28Phases of Wound Repair
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...