Related Experiment Video
Updated: Sep 30, 2026

Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas
Published on: February 28, 2019
Benign Sinonasal Tumors: A 17-Year Single Center Experience
Hakan Kara1, Kağan Avcı1, Vedat Emre Alayoğlu1
1İstanbul University, İstanbul Faculty of Medicine, Department of Otorhinolaryngology-Head and Neck Surgery, İstanbul, Türkiye.
Objective:
This study evaluated demographic characteristics, histopathological distribution, surgical approaches, residual disease, complications, and recurrence patterns in patients surgically treated for benign sinonasal tumors.
Methods:
Medical records of patients who underwent surgery for benign sinonasal tumors at a single tertiary center between January 2007 and December 2024 were retrospectively reviewed. Patients with less than three months of follow-up were excluded. Demographic, histological, surgical, complication, residual disease, follow-up, and recurrence data were analyzed according to tumor type.
Results:
A total of 368 patients were included. The median age was 42.5 years, and 260 patients (70.7%) were male. The most common histological groups were sinonasal papilloma (34.2%), osseous lesions (22.6%), and juvenile nasopharyngeal angiofibroma (19.0%). Surgical approach differed significantly by tumor type (p<0.001), with endoscopic surgery used most frequently overall (74.5%). Residual disease also differed significantly among tumor types (p=0.011) and was most common in osseous lesions. Complications occurred in 17.4% of patients; complication types varied significantly across tumor groups (p=0.035). Recurrence data were available for 326 patients, and recurrence occurred in 40 patients (12.3%), most frequently in juvenile nasopharyngeal angiofibroma (23.4%; p=0.010).
Conclusion:
Histological subtype was associated with surgical approach, residual disease, complication pattern, and recurrence. These findings support individualized surgical planning and histology-specific follow-up in benign sinonasal tumors.
