PRP-Integrated Conductive Hydrogels With Dynamic Crosslinking for Accelerated Wound Healing and Physiological...

The capability to simultaneously promote wound healing and enable real-time monitoring is critical for effective wound management, especially in dynamic and infection-prone regions such as joints, yet unmet needs remain in clinical practice. Herein, we present a multifunctional hydrogel dressing composed of gold nanoparticles (AuNPs), Ti₃C₂T_x MXene, poly(acrylamide), and platelet-rich plasma (PRP), designed to both accelerate tissue regeneration and provide continuous physiological monitoring. The integration of surface-functionalized MXene and AuNPs introduces both dynamic and covalent bonding connections (hydrogen, covalent, and Au─S bonds), endowing the hydrogel with remarkable stretchability (∼1000%), rapid self-healing, and robust wet tissue adhesion to accommodate skin deformation during motion. PRP further enhances angiogenesis, collagen remodeling, and cell proliferation, significantly improving in vivo healing outcomes. Crucially, the hydrogel's conductive and thermo-responsive matrix enables resistance-based sensing of local temperature changes, offering continuous, noninvasive feedback on wound status. This dual-functional platform unites regenerative bioactivity with electronic responsiveness, addressing urgent clinical needs for adaptive healing and intelligent diagnostics, which is thus providing a promising strategy for next-generation smart dressings in wearable and personalized medicine.