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Updated: Oct 1, 2026
Breathing-controlled Electrical Stimulation (BreEStim) for Management of Neuropathic Pain and Spasticity
Published on: January 10, 2013
Scrambler Therapy for Neuropathic Pain After Spinal Cord Injury: Two Case Reports
Zhu Wang1, Philippines Cabahug2, Thomas J Smith3
1Division of General Internal Medicine, Section of Palliative Medicine, Department of Medicine, Johns Hopkins Medical School, Baltimore, Maryland.
Abstract:
Neuropathic pain after spinal cord injury (SCI) is common and often refractory to treatment. Scrambler Therapy (ST) is a noninvasive neuromodulation approach that delivers synthetic "nonpain" signals via cutaneous electrodes. We report 2 cases of SCI-related neuropathic pain treated with ST. One patient experienced transient and inconsistent relief, while the other achieved substantial, durable improvement with functional recovery and complete response after retreatment. ST was well tolerated with minimal adverse effects. These cases highlight variable response and support further study of ST as a potential treatment for refractory SCI-related neuropathic pain.
