Genetic heterogeneity in hyperkeratosis palmaris et plantaris

More than one form of 'simple' hyperkeratosis palmaris et plantaris (tylosis) probably exists. Two unrelated patients showing hyperkeratosis of relatively late onset have been found who developed esophageal carcinoma, while previously reported families with dominantly inherited esophageal cancer and with esophageal stricture, also showed late onset of hyperkeratosis. In contrast the more usual families with onset of hyperkeratosis in the first six months of life show no association with esophageal or other disease.