Related Experiment Videos
Refractory Iron-deficiency anemia and intermittent melena in phenotypic type 2 Glanzmann thrombasthenia: a diagnostic
Fengxia Zhang1, Zengguang Ma2, Ruohan Yang3
1Medical Laboratory Center, Hengshui Health Technology Vocational College.
Abstract:
Glanzmann thrombasthenia (GT) is a rare platelet disorder caused by quantitative or qualitative defects of glycoprotein (GP) IIb/IIIa, leading to impaired platelet aggregation[1]. Classic hereditary GT, when molecularly confirmed, typically manifests with lifelong mucocutaneous bleeding, whereas gastrointestinal bleeding is uncommon and usually presents as overt hemorrhage. Here we report a case of phenotypic type 2 GT characterized predominantly by iron-deficiency anemia and intermittent melena. GT was considered a potential contributing factor based on systematic diagnostic reasoning. This case highlights the necessity of platelet function evaluation in selected clinical scenarios, particularly for gastroenterologists when routine endoscopic evaluations yield negative results.
Related Concept Videos
Type II Diabetes Mellitus III: Clinical Manifestations and Diagnosis
Gastritis III: Clinical Manifestations and Management
Clinical manifestations of acute gastritis
The patient with acute gastritis may have a rapid onset of symptoms, such as epigastric pain or discomfort, dyspepsia, anorexia, hiccups, or nausea and vomiting, which can last from a few hours to a few days. Erosive or hemorrhagic gastritis may cause bleeding, which may manifest as blood in vomit or as...
Esophageal Varices-II: Clinical Features and Management
In the initial assessment, a thorough review of the patient's medical history is vital to identify risk factors such as liver disease, alcohol abuse, or...
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the colonic...
Serum Laboratory Studies, Stool Test, Breath Test
Barrett Esophagus-II: Clinical Manifestations and Management
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure entails...