Related Experiment Video
Updated: Oct 2, 2026

Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease
Published on: April 4, 2018
A genetic variant of long non-coding RNA TINCR is associated with psoriasis in the Turkish population
Egemen Akgun1, Fadime Mutlu Icduygu2, Burak Aksan3
1Department of Medical Biology, Faculty of Medicine, Giresun University, Giresun, Turkey.
Background:
TINCR and H19 are long non-coding RNAs known to be involved in keratinocyte proliferation and differentiation. The objective of this study was to investigate the contribution of TINCR rs2288947 and H19 rs217727 polymorphisms to the pathogenesis of psoriasis.
Methods:
The study group comprised 284 patients with psoriasis and 253 healthy controls. Real-time PCR method was used for genotyping of rs2288947 and rs217727 polymorphisms.
Results:
In rs2288947 polymorphism, AA genotype (BH-adjusted p = 0.014, adjusted OR = 1.92, 95% CI 1.20‒3.09), combined genotypes GA+AA (BH-adjusted p = 0.021, adjusted OR = 1.64, 95% CI 1.10‒2.45) and A allele (BH-adjusted p = 0.014, adjusted OR = 1.39, 95% CI 1.10‒1.76) showed a significant association with psoriasis. For H19 rs217727, results were inconclusive, reflecting limited precision of the effect estimates in our study cohort (overall genotype distribution, p = 0.425), and despite high genotyping quality, control genotype distributions deviated from Hardy-Weinberg equilibrium.
Conclusion:
Our findings indicate that the TINCR rs2288947 polymorphism may be associated with an elevated risk of psoriasis in this Turkish cohort. H19 rs217727 showed no significant association; given the breadth of the confidence intervals, this result is best viewed as inconclusive. Independent replication and functional assays will help clarify biological relevance.
Related Concept Videos
lncRNA - Long Non-coding RNAs
Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase
Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu
Genome-wide Association Studies-GWAS
GWAS does not require the identification of the target gene involved in...
Non-LTR Retrotransposons
Comparing Copy Number Variations and SNPs
Copy number variations or CNVs are the structural variations that cover more than 1kb of DNA sequence. The single nucleotide polymorphism (SNP), on the other hand, is a single nucleotide change or a point mutation that is found in more than 1%...