Related Experiment Video
Updated: Oct 2, 2026
Green Synthesis, Characterization, Encapsulation, and Measurement of the Release Potential of Novel Alkali Lignin Micro-/Submicron Particles
Published on: March 1, 2024
Comparing polysaccharides in microfluidic-fabricated Zein-based lutein ternary composite nanoparticles: enhanced
Zijian Qiu1, Xueqing Pan1, Yumeng Miao1
1Tianjin International Cooperation Research Centre of Food Nutrition/Safety and Medicinal Chemistry, College of Biotechnology, Tianjin University of Science & Technology, Tianjin 300457, China.
Abstract:
Lutein's (Lut) food application is hindered by poor aqueous solubility, low stability, and limited bioaccessibility. In this study, Zein-based Lut-loaded nanoparticles (Lut-NPs) were fabricated via an intelligent microfluidic platform using four polysaccharides: sodium alginate (ALG), pectin (PEC), sodium carboxymethyl cellulose (CMC), and chondroitin sulfate (CHS), to systematically compare delivery performance. Lut-PEC-NPs and Lut-CHS-NPs presented optimal comprehensive performance, with small particle sizes (<104 nm), low PDI (<0.25), high encapsulation efficiency, and excellent antioxidant capacity (DPPH: 97.12%; ABTS: 92.28%). Both exhibited uniform spherical morphology and robust environmental stability. Simulated digestion confirmed sustained Lut release and prominently improved bioaccessibility (65.88% for PEC, 82.38% for CHS), nearly three-fold higher than free Lut. Molecular simulations revealed that hydrophobic, electrostatic, and hydrogen-bonding interactions synergistically drove nanoparticle assembly and stability. This study identifies PEC and CHS as ideal coating materials and provides a reliable microfluidic strategy for Lut delivery in the food industry.
