Related Experiment Videos
RNA modifications and metabolism in cancer: mechanisms, cross-talk and therapeutic implications
Xin Luo1, Xinzhao Zuo1, Jingke He1
1Department of Obstetrics and Gynecology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Abstract:
RNA modifications, particularly in the realm of epitranscriptomics, have emerged as crucial regulatory factors in cancer progression, influencing cancer cell behavior by reprogramming metabolic pathways. These modifications, such as N⁶-methyladenosine (m⁶A), 5-methylcytosine (m⁵C), N¹-methyladenosine (m¹A), N⁷-methylguanosine (m⁷G), N⁴-acetylcytidine (ac⁴C) and pseudouridine (Ψ), modulate mRNA stability, splicing, translation efficiency, and non-coding RNA function, thereby fine-tuning the expression of metabolic enzymes and transporters. Importantly, these marks converge on shared metabolic enzymes, engage common effector proteins, and exhibit synergistic, antagonistic or hierarchical relationships that collectively shape the metabolic landscape of tumors. This review synthesizes current knowledge on how RNA modifications coordinate glucose, lipid, glutamine and nucleotide metabolism, with emphasis on cross-talk and functional integration among different marks. We further discuss tumor-type-specific wiring of these networks, the challenges of multi-modification detection, and the therapeutic potential of targeting the epitranscriptomic-metabolic axis in precision oncology.
Related Concept Videos
Adaptive Mechanisms in Cancer Cells
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Adaptive Mechanisms in Cancer Cells
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Cancer
mTOR Signaling and Cancer Progression
The mTOR pathway or the...
mTOR Signaling and Cancer Progression
The mTOR pathway or the...
Interactions Between Signaling Pathways
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...