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Updated: Oct 3, 2026

Implementation of In Vitro Drug Resistance Assays: Maximizing the Potential for Uncovering Clinically Relevant Resistance Mechanisms
Published on: December 9, 2015
Drug resistance reversal: an overview of real world success stories
1ISEM, Université de Montpellier, CNRS, IRD, EPHE, Montpellier, Campus Triolet, Montpellier Cedex 05 34095, France.
Abstract:
This perspective provides an overview of what we know from real-world data on reversal of drug resistance evolution. An important question for those who study drug resistance is whether it is possible to reverse the evolution of resistance, for example by halting the use of specific drugs for a patient or even a community or country. Evidence for successful reversal of resistance levels is spread out in many different subfields of infectious disease. I use examples from P. falciparum malaria, several bacterial species including E. coli, M. tuberculosis, and S. aureus, and the viral pathogen HIV, to show that it is possible to reverse the evolution of resistance.
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