Intra-Breath Oscillometry Reveals Phase-Dependent Resistive Abnormalities in Respiratory Mechanics After Severe...

Post-COVID syndrome is often associated with persistent respiratory symptoms despite largely unremarkable conventional pulmonary function tests, suggesting the presence of subtle alterations in respiratory mechanics. We hypothesized that phase-resolved analysis of respiratory impedance would reveal dynamic abnormalities not captured by standard endpoint-based measures. In this prospective observational study, survivors of severe COVID-19 requiring veno-venous extracorporeal membrane oxygenation (V-V ECMO) (n = 9) were evaluated two years after recovery and compared with matched healthy controls (n = 9). Respiratory system impedance was assessed using intra-breath oscillometry at 5 Hz. Phase-dependent mechanical behavior was characterized by inspiratory-expiratory differences in phase-averaged resistance and reactance (ΔR_av, ΔX_av), end-tidal differences (ΔR_end, ΔX_end), and resistance and reactance loop areas (R_loop, X_loop). Post-COVID patients exhibited significantly elevated end-expiratory resistance (p = 0.02), whereas end-inspiratory resistance did not differ significantly between groups. ΔR_av (p = 0.01) and R_loop (p = 0.03) were reduced compared with controls, while ΔR_end, ΔX_av, ΔX_end and X_loop did not differ significantly. These findings indicate altered phase-dependent mechanics in post-COVID patients, characterized by elevated end-expiratory resistance and attenuated within-breath resistance modulation. Intra-breath analysis of respiratory impedance thus provides complementary information on time-varying respiratory mechanics beyond conventional whole-breath oscillometry and may enable more sensitive characterization of subtle mechanical dysfunction.