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Updated: Oct 3, 2026

Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo
Published on: January 7, 2019
A novel oncolytic peptide synergizing with immunotherapy
Guido Kroemer1,2,3, Xiaolian Deng1,2, Baldur Sveinbjørnsson4
1Inserm, Centre de Recherche des Cordeliers, Equipe labellisée Par la Ligue Contre le Cancer, Université Paris Cité, Sorbonne Université, Institut Universitaire de France, Paris, France.
Abstract:
In a recent paper published in Nature, Yuan et al. described an acid-responsive membranolytic peptide that temporally separates lysosomes from later plasma membrane rupture, thereby converting oncolysis into immunogenic cell death. This elegant design permits systemic administration, elicits antigen-specific immunity, and sensitizes tumors to programmed death ligand 1 blockade with remarkably limited toxicity.
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