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Updated: Oct 3, 2026

Optimization of Synthetic Proteins: Identification of Interpositional Dependencies Indicating Structurally and/or Functionally Linked Residues
07:08

Optimization of Synthetic Proteins: Identification of Interpositional Dependencies Indicating Structurally and/or Functionally Linked Residues

Published on: July 14, 2015

Synonymous sequence design controls the folding, processing, and activity of the therapeutic protein ADAMTS13

Katarzyna I Jankowska1, Upendra K Katneni1, Brian C Lin1

  • 1Division of Hemostasis, Office of Therapeutic Products, Center for Biologics Evaluation and Research, US FDA, Silver Spring, MD, USA.

Trends in Biotechnology
|October 1, 2026
PubMed

Keywords:
ADAMTS13AnkyronMDTCScodon optimizationcodon-pair optimizationprotein folding

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