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Updated: Oct 5, 2026

Microwave-assisted Intramolecular Dehydrogenative Diels-Alder Reactions for the Synthesis of Functionalized Naphthalenes/Solvatochromic Dyes
Published on: April 1, 2013
Molecular rearrangements as powerful tools in diversity-oriented natural products synthesis: a review
Noor Fatima1, Ameer Fawad Zahoor1, Muhammad Jawwad Saif2
1Department of Chemistry, Government College University Faisalabad 38000-Faisalabad Pakistan fawad.zahoor@gcuf.edu.pk mssaeed@iu.edu.sa.
Abstract:
Molecular rearrangements play a significant role in organic synthesis as these are involved in the construction of intricate molecular frameworks by modifying the carbon skeleton and functional groups. Most of the molecular rearrangements result in stereospecific products. Several molecular rearrangements have been found to play a vital role in the synthesis of natural products with diverse biological potential. The current review article highlights the molecular rearrangements enabled facile access to complex scaffolds of biologically potent natural products covering the data from 2021 to date. Recent synthetic applications of various molecular rearrangements towards the total synthesis of diverse natural products specifically terpenoids, alkaloids and polyketides have been summarized here.
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