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Experimental and Imaging Techniques for Examining Fibrin Clot Structures in Normal and Diseased States
Published on: April 1, 2015
Fibrinogen as a Molecular Bridge Linking SARS-CoV‑2 Immune Evasion and Endothelial Access?
Saroj Kumar Panda1, Shashi Singh2, Parth Sarthi Sen Gupta2
1Department of Chemistry and Biochemistry, University of Texas at Arlington, Arlington, Texas 76019, United States.
Abstract:
SARS-CoV-2 exploits multiple cellular entry routes. Beyond ACE2-mediated entry, we propose that the spike protein binds fibrinogen not only to facilitate immune evasion but also to position the receptor-binding domain for integrin-mediated uptake. This molecular bridge may enhance viral RNA delivery to endothelial cells. Targeting the spike protein-fibrinogen interface could open new therapeutic avenues for acute and post-COVID vascular disease.
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