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Liver involvement in secondary syphilis.

S S Pareek

    Digestive Diseases and Sciences
    |January 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Secondary syphilis can cause liver enzyme abnormalities, particularly elevated alkaline phosphatase. Treatment of syphilis resolves these liver function issues, as seen in a study of 18 patients.

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    Area of Science:

    • Hepatology
    • Infectious Diseases
    • Biochemistry

    Background:

    • Secondary syphilis is a systemic infection that can affect multiple organs.
    • Liver involvement in secondary syphilis is not uncommon, but its biochemical and histological features require further elucidation.

    Purpose of the Study:

    • To assess liver function biochemically in patients with secondary syphilis.
    • To correlate biochemical findings with liver biopsy results.
    • To evaluate the impact of syphilis treatment on liver function.

    Main Methods:

    • Biochemical assessment of liver function tests in 18 patients with secondary syphilis.
    • Liver biopsy performed in 6 patients prior to treatment.
    • Monitoring of liver function post-treatment.

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    Main Results:

    • Abnormal liver enzymes were detected in 9 out of 18 patients.
    • Elevated alkaline phosphatase was the most consistent biochemical abnormality.
    • Liver biopsies showed mononuclear cell infiltration around central veins and portal tracts.
    • All biochemical abnormalities normalized after treatment for syphilis.

    Conclusions:

    • Secondary syphilis can lead to transient biochemical liver abnormalities.
    • Elevated alkaline phosphatase is a common indicator of hepatic involvement.
    • Liver biopsy findings are consistent with an inflammatory process.
    • Effective treatment of syphilis resolves hepatic dysfunction.