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Updated: Oct 5, 2026

System for Efficacy and Cytotoxicity Screening of Inhibitors Targeting Intracellular Mycobacterium tuberculosis
Published on: April 5, 2017
Revisiting the potential of elongation factors as drug targets for pathogenic mycobacteria
Mushtaq Ahmad Wani1, Shivani Gurjar2, Ajay Kumar2
1Department of Pharmacoinformatics, National Institute of Pharmaceutical Education and Research, S.A.S. Nagar, Punjab 160062, India.
Abstract:
Drug-resistant Mycobacterium tuberculosis and non-tuberculous mycobacteria infections are a threat to global healthcare. The scarcity of therapeutic options highlights the urgent necessity to discover efficacious drug targets and inhibitors. Protein synthesis has been clinically proven to be an excellent target for antibiotic development. Translation involves three well-defined steps: initiation, elongation and termination. The crucial elongation stage utilizes elongation factors (EFs: EF thermo unstable, EF thermo stable and EF G) that facilitate the sequential addition of amino acids. This review provides a perspective on the potential of mycobacterial EFs as innovative targets because of their vital role in translation, trans-translation and other alternative functions.
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