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Updated: Oct 6, 2026
A Double Humanized BLT-mice Model Featuring a Stable Human-Like Gut Microbiome and Human Immune System
Published on: August 30, 2019
Natural microbiota-based mouse models: A platform to fast-track translation of fundamental discoveries into the
Mario Gößwein1,2, Isabel Ulmert3, Stephan P Rosshart1,2
1Department of Microbiome Research, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
Abstract:
Conventional laboratory mice are invaluable tools in biomedical research, but their restricted microbial complexity limits their translational relevance. Several streams of evidence now indicate that (re)colonizing laboratory mice with a naturally evolved microbiota more faithfully recapitulates key features of the human physiological response. Here, we outline where natural microbiota-based models can improve the investigation of human disease, and how findings in such models bear on several aspects of translational biomedical research.
