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Updated: Oct 12, 2026

A Microplate Assay to Assess Chemical Effects on RBL-2H3 Mast Cell Degranulation: Effects of Triclosan without Use of an Organic Solvent
Published on: November 1, 2013
[The allergenic effect of rubber accelerators tetramethyl thiuram disulfide (TMTD) and mercaptobenzothiazole (MBT)]
Abstract:
The eczematogenic effects of tetramethylthiuramidsulfid and of mercaptobenzothiazol were studied on the basis of an inquiry in establishments using TMTD and MBT, a frequency analysis of positive reactions of our standard series in 1971 and testing of various rubber articles on sensitized persons as well as animal experiments. The results indicate a wider use, a higher percentage of positive epicutaneous tests and also a higher sensitizing potency in the animal test of the TMTD as compared with MBT. MBT was removed from our standard series.
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