Related Experiment Video
Updated: Oct 7, 2026

Preparation of Stable Bicyclic Aziridinium Ions and Their Ring-Opening for the Synthesis of Azaheterocycles
Published on: August 22, 2018
Total synthesis of myxadazoles A1, A2, and B
Laxman D Nandawadekar1,2, Yashika Tandon1, Choppari Thirupathi3
1Department of Organic Synthesis & Process Chemistry, CSIR-Indian Institute of Chemical Technology (CSIR-IICT), Hyderabad 500007, India. ds.reddy.iict@csir.res.in.
Abstract:
Herein, we report the first total synthesis of myxadazoles A1, A2, and B, natural products isolated from Myxococcus sp. SDU36. The concise synthetic route features efficient reductive aminations for installation of the ribose moiety and fatty acid side chain, a 1,3-dipolar cycloaddition for isoxazole construction, and late-stage benzimidazole formation. Starting from inexpensive, readily available materials, this strategy provides practical access to the natural products and enables the rapid synthesis of diverse myxadazole analogues.
Related Concept Videos
Stability of Substituted Cyclohexanes
The two chair conformations of cyclohexanes undergo rapid interconversion at room temperature. Both forms have identical energies and stabilities, each comprising equal amounts of the equilibrium mixture. Replacing a hydrogen atom with a functional group makes the two conformations energetically non-equivalent.
For example, in...
Preparation of 1° Amines: Hofmann and Curtius Rearrangement Overview
Prochirality
Antifungal Agents
Disubstituted Cyclohexanes: cis-trans Isomerism
In cyclohexane, the substituents can occupy different positions generating distinct isomers.
