Related Experiment Video
Updated: Oct 7, 2026
Robotically Delivered fMRI-Guided Personalized Transcranial Magnetic Stimulation Therapy for Treatment-Resistant Depression
Published on: April 10, 2026
Dose effect of bilateral transcranial magnetic stimulation for depression and anxiety in a real-world clinical
Noah Marchuck1, Raneeka DeMoss1, William C Turner2
1Skyland Trail, USA.
Abstract:
Transcranial Magnetic Stimulation (TMS) is a non-invasive intervention for treatment-resistant depression (TRD). Comorbid anxiety is common in TRD patients. We examined the effect of single-dose versus high-dose bilateral TMS on depression and anxiety.
Methods:
Seventy-eight patients received 1 Hz right dorsolateral prefrontal cortex (DLPFC) stimulation combined with left single-dose or high-dose iTBS to the left DLPFC at a nonprofit clinic. Depression and anxiety symptoms were measured at baseline, after 10 and 20 sessions, and final (30-36) TMS sessions.
Results:
Bilateral TMS resulted in a significant decrease in depression (F(3,70)= 9.670, p < .001; 74.4% response, 47.7% remission) and anxiety (F(3,70)= 4.916, p = 0.004, 52.6% response, 39.7% remission). The high-dose group showed a faster reduction in depression (F(3,70)= 2.875, p = 0.042), but not anxiety symptoms. There was no dose difference at the final session.
Conclusion:
Bilateral TMS improved depression and anxiety symptoms with a quicker reduction in depression symptoms with higher dosing, which highlights an important clinical consideration to reduce visits.
