A detection-task-specific deep-learning method to improve the quality of sparse-view myocardial perfusion SPECT...

Myocardial perfusion imaging (MPI) with single-photon emission computed tomography (SPECT) is a widely used and cost-effective diagnostic tool for coronary artery disease. However, the lengthy scanning time in this imaging procedure can cause patient discomfort, motion artifacts, and potentially inaccurate diagnoses due to misalignment between the SPECT scans and the CT scans, which are acquired for attenuation compensation. Reducing projection angles is a potential way to shorten scanning time, but this can adversely impact the quality of the reconstructed images. To address this issue, we propose a detection-task-specific deep-learning method for sparse-view MPI SPECT images. This method integrates an observer loss term that penalizes the loss of anthropomorphic channel features with the goal of improving performance in perfusion defect-detection task. We observed that, on the task of detecting myocardial perfusion defects, the proposed method yielded an area under the receiver operating characteristic (ROC) curve (AUC) significantly larger than the sparse-view protocol. Further, the proposed method was observed to be able to restore the structure of the left ventricle wall, demonstrating ability to overcome sparse-sampling artifacts. Our preliminary results motivate further evaluations of the method.