Related Experiment Video
Updated: Oct 8, 2026
Ultrasonographic Evaluation of Salivary Glands for Sjogren's Syndrome: Diagnostic and Monitoring Insights
Published on: October 13, 2023
Integrating Histological and Molecular Findings for Practical Salivary Gland Diagnostics
1BC Cancer Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada. jinesa.moodley@bccancer.bc.ca.
Purpose:
The purpose of this review paper is to provide an integrative algorithmic approach to the diagnosis of salivary gland tumors, including pertinent histologic features, immunohistochemical patterns and molecular driver mutations and/or fusions.
Methods:
Review of the literature was performed to provide an up-to-date synopsis of salivary gland tumors, in a concise and summarized format.
Results:
Diagnostic workflow algorithms are created and included to complement the histomorphologic subgroups, to provide a user-friendly tool when approaching salivary gland tumors in routine surgical pathology.
Conclusion:
Histomorphologic features and immunophenotype of majority of salivary gland tumors, including select molecular surrogate immunohistochemical stains, are the most important starting point in diagnostic interpretation. Molecular data can provide an additional data point for further supporting evidence and/or to aid in challenging cases.
