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Updated: Oct 8, 2026

Synthesis of Triazole and Tetrazole-Functionalized Zr-Based Metal-Organic Frameworks Through Post-Synthetic Ligand Exchange
Published on: June 23, 2023
Solvent influenced synthesis, crystal structures and urease inhibition of copper(II) complexes derived from
Yang-Lei Li1, En-Jun Zhang2, Can Luo2
1Key Laboratory of Low-Cost Rural Environmental Treatment Technology of Sichuan Provincial Education Department, Sichuan University of Arts and Science, Dazhou 635000, P. R. China; Xi'an University of Architecture and Technology, School of Metallurgical Engineering, Xi'an 710055, P. R. China.
Abstract:
Thiosemicarbazones have broad biological activities and play important role in coordination chemistry. In this work, three new copper(II) complexes, [Cu2LCl(µ-Cl)(EtOH)2]Cl (1), [CuL(OH2)]NO3·H2O (2), and [CuL(EtOH)]NO3·EtOH (3), where L is the deprotonated form of 2-hydroxy-3-methoxybenzaldehyde thiosemicarbazone (HL), were prepared and characterized by physico-chemical methods. Crystal structures of the complexes are further confirmed by single crystal X-ray determination. Complex 1 has a dinuclear copper(II) structure, and complexes 2 and 3 have mononuclear copper(II) structures. Inhibitory effect of the complexes on Jack bean urease was assayed. The complexes have remarkable activity with IC50 values of 0.3-1.1 μmol L-1.
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