Facile synthesis of trans racemic 1,4-diaryl substituted, proline esters via Ugi multicomponent reaction

Diaryl-substituted pyrrolidine derivatives are prevalent in numerous biologically active compounds and represent important scaffolds in medicinal chemistry. However, their synthesis remains challenging due to limitations associated with direct functionalization of the pyrrolidine ring. This work describes a facile synthesis of 1,4-diaryl-substituted pyrrolidine derivatives via Ugi multicomponent coupling reaction. The strategy enables the convergent assembly of highly functionalized pyrrolidine frameworks from readily available aromatic building blocks, thereby providing an effective alternative to conventional functionalization approaches. The operational simplicity and modularity of this method offer a practical and versatile route to pyrrolidine scaffolds of relevance to both synthetic and medicinal chemistry.