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Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
Published on: January 19, 2016
5-Cyclo-propyl-1-[(4-methyl-benzene)-sulfon-yl]indole-2-carbaldehyde
Veeranjaneyulu Avula1,2, Keerthana V K2, N D Yash3
1Department of Chemistry REVA University, Rukmini Knowledge Park Kattigenahalli Yelahanka Bangalore 560064 Karnataka India.
Abstract:
The crystal structure of the title compound, C19H17NO3S, was determined by single-crystal X-ray diffraction. The compound crystallizes in the monoclinic crystal system with space group P21/c. The indole ring is essentially planar, with cyclo-propyl, aldehyde and p-toluene-sulfonyl groups attached at the C5, C2 and N1 positions, respectively. The aldehyde substituent is nearly coplanar with the indole ring, while the cyclo-propyl and p-tolyl rings are almost perpendicular to it. The crystal packing is mainly influenced by slipped π-π stacking inter-actions, along with weak C-H⋯O inter-actions involving the sulfonyl oxygen atoms. Hirshfeld surface analysis shows that H⋯H (46.6%), O⋯H/H⋯O (23.5%), C⋯H/H⋯C (16.0%) and C⋯C (8.0%) contacts make the major contributions to the crystal packing.
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