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Updated: Oct 9, 2026

Investigation of Protein Recruitment to DNA Lesions Using 405 Nm Laser Micro-irradiation
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Published on: March 20, 2018

XPA lactylation is required for UV-induced DNA damage repair

Jie Yang1,2, Xin Ding3,4, Zhikai Zeng1,2

  • 1Jiangxi Provincial Key Laboratory of Respiratory Diseases; Jiangxi Institute of Respiratory Diseases; Jiangxi Clinical Research Center for Respiratory Diseases; Department of Thoracic Surgery, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang 330006, China.

Nucleic Acids Research
|October 7, 2026
PubMed

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Nucleotide Excision Repair

Exposure to mutagens can damage DNA and result in bulky lesions that distort the double-helix structure or impede proper transcription. Damaged DNA can be detected and repaired in a process called nucleotide excision repair (NER). NER employs a set of specialized proteins that first scan DNA to detect a damaged region. Next, NER proteins separate the strands and excise the damaged area. Finally, they coordinate the replacement with new, matching nucleotides.DNA distortion and damageCells are...
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Cells are regularly exposed to mutagens—factors in the environment that can damage DNA and generate mutations. UV radiation is one of the most common mutagens and is estimated to introduce a significant number of changes in DNA. These include bends or kinks in the structure, which can block DNA replication or transcription. If these errors are not fixed, the damage can cause mutations, which in turn can result in cancer or disease depending on which sequences are...
Nucleotide Excision Repair01:46

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