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Updated: Oct 9, 2026

Extracellular Glucose Depletion as an Indirect Measure of Glucose Uptake in Cells and Tissues Ex Vivo
Published on: April 6, 2022
Exogenous Carbohydrate Metabolism Under Energy Deficit and Environmental Stress
Lee M Margolis1,2, François Haman3, John P O'Hara4
1Military Nutrition Division, U.S. Army Research Institute of Environmental Medicine, Natick, MA, USA.
Abstract:
Physiological stress of environmental exposure and energy deficit impairs the absorption, transport, and utilization of exogenous carbohydrate for fuel during exercise. Blunted exogenous carbohydrate oxidation may require alternative fueling strategies to optimize carbohydrate metabolism to support physical performance. This review will overview the impact of physiological stress on exogenous carbohydrate oxidation and potential interventions to support physical performance. Summary: Physiological stress exposure limits the effectiveness of carbohydrate supplementation to spare endogenous substrate oxidation by impeding exogenous carbohydrate oxidation.
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