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Does the DOOR Account for Post-randomization Treatment Modification or Incorporate It?
Praveen Kumar Tirlangi1, Nitin Gupta1
1Department of Infectious Diseases, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka- 576104, India.
Abstract:
This correspondence clarifies that DOOR incorporates, rather than causally accounts for, post-randomization treatment modification. In the voriconazole-amphotericin B trial, frequent treatment switching means the reported DOOR probability reflects treatment strategies as implemented, not sustained randomized monotherapy throughout the original trial.
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