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Updated: Oct 9, 2026

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
Published on: June 2, 2014
Migraine
Cristina Tassorelli1, Shuu-Jiun Wang2, Patricia Pozo-Rosich3
1Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy; Istituto di Ricovero e Cura a Carattere Scientifico Casimiro Mondino Foundation, Pavia, Italy.
Abstract:
Migraine is a chronic neurovascular disorder characterised by recurrent attacks of moderate-to-severe head pain, accompanied by transient but disabling symptoms such as aura, nausea, vomiting, phonophobia, and photophobia, reflecting the involvement of multiple systems. Migraine affects and disables a large proportion of the global population. The pathogenesis of migraine involves the interplay of genetic and epigenetic factors across complex neurosensory and neurovascular networks. Decades of research have elucidated key components of these pathways, driving the development of mechanism-based therapies that are now transforming clinical practice and substantially improving patients' lives.
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