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Updated: Oct 9, 2026
Measuring the Rate of Lipolysis in Ex Vivo Murine Adipose Tissue and Primary Preadipocytes Differentiated In Vitro
Published on: March 17, 2023
More than just adipose. The impact of GLP1Ra on lean tissue
Maxime Julien1,2, Stewart Jeromson1,2, David C Wright1,2
1School of Kinesiology, University of British Columbia, Vancouver, British Columbia Canada.
Abstract:
Glucagon-like peptide 1 receptor agonists (GLP1Ra) are widely used for the management of obesity and cardiometabolic disease. While causing robust weight loss, GLP1Ra also result in reductions in lean tissue, including skeletal muscle and bone. The purpose of the current review is to discuss key findings demonstrating the effects of GLP1Ra treatment on skeletal muscle and bone, approaches that have been implemented to mitigate these changes, and to highlight important areas of future research.
