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Identification of the Novel HLA-G*01:01:39 Allele Using PolyseqOne Sequencing

Xia Zhao1, Musheng Shen1, Jia Shen1

  • 1Ordos Central Blood Station, Ordos, Inner Mongolia, China.

HLA
|October 7, 2026
PubMed

Abstract:

HLA-G*01:01:39 differs from HLA-G*01:01:05 by a single synonymous nucleotide substitution (T>A) at codon 107 in exon 3.

Keywords:
HLA‐GPolyseqOnenanopore sequencingnovel allele

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Single Nucleotide Polymorphisms-SNPs01:05

Single Nucleotide Polymorphisms-SNPs

A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...

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