Ovarian Carcinosarcoma With Neuroendocrine Differentiation: A Case Report

We report a case of advanced-stage ovarian carcinosarcoma (OCS) with extensive extra-ovarian involvement and widespread high-grade serous carcinoma involving the omentum, bladder, ileal mesentery, and small bowel serosa in a female patient in her mid-40s. This case highlights a rare arrangement of histologic features and disease differentiation. The metastatic sites demonstrated predominantly epithelial high-grade serous carcinoma, while the sarcomatous component was identified in the adnexal tumor and left pelvic sidewall. The presence of neuroendocrine differentiation, however, represents a rare and infrequently reported histopathologic feature. The case demonstrates the importance of comprehensive histopathologic and immunohistochemical evaluation in accurately characterizing complex gynecologic malignancies.