Platelet-rich plasma for managing diabetic foot ulcers and preparation procedure reporting: a narrative review

Diabetic foot ulcers (DFUs) affect many patients with uncontrolled diabetes and are associated with significant morbidity. Platelet-rich plasma (PRP) preparations have been validated as effective adjuncts in the treatment of DFUs. This narrative review seeks to appraise and critique literature related to PRP use for DFUs. As a result, the inconsistent reporting of statistical analyses and preparation procedures among studies are highlighted. In 2017, the Minimum Information for Studies Evaluating Biologics in Orthopaedics (MIBO) guideline was compiled to standardise the reporting of orthobiologic studies. Studies prior to 2017 would, understandably, not include adequate reporting of their preparation; however, some research after 2017 is still lacking thorough reporting of preparation procedures. Although some of the studies presented in this review demonstrate adequate adherence to guidelines, others exhibit a lack of reporting standards, specifically in terms of the preparation of PRP. In addition, the absence of comprehensive statistical analysis in the studies presented remains an issue, as it limits readers' ability to draw conclusions and compare results across a diverse set of studies. As PRP becomes more prevalent in the treatment of DFUs, there is an increased need for standardised preparation and reporting in investigational studies. There are existing guidelines for reporting, but these are not always followed in the literature. In future studies, an effort should be made to ensure consistent reporting.