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Updated: Oct 10, 2026

From Molecules to Materials: Engineering New Ionic Liquid Crystals Through Halogen Bonding
Published on: March 24, 2018
Flexible ether chain-bridged dicationic ionic liquid stationary phase for multifunctional separation and interaction
Xiang Wang1, Shihong Wang2, Hongxiang Zhan3
1Key Laboratory of Micro-Nano Powder and Advanced Energy Materials of Anhui Higher Education Institutes, Chizhou University, Chizhou, Anhui, 247000, PR China; School of Chemistry and Materials Science, University of Science and Technology of China, Hefei, Anhui, 230026, PR China.
Abstract:
Dicationic ionic liquids (DILs) possess higher thermal stability and more abundant interaction sites than monocationic ionic liquids. A novel ether chain-bridged dicationic ionic liquid (EDIL) was synthesized and immobilized onto silica via crosslinking polymerization to prepare a mixed-mode stationary phase (Sil-PEDIL). The stationary phase efficiently separated diverse analytes, including nucleosides, phthalates, and fluorobenzoic acid isomers, achieving a maximum column efficiency of 85,950 plates m-1. Sil-PEDIL also exhibited stable retention and improved peak shapes under pure aqueous mobile phase conditions compared with HILIC. Chromatographic studies revealed a mixed-mode retention mechanism involving HILIC, RPLC, and IEC. Quantum chemical calculations demonstrated the conformational flexibility of EDIL and its adaptive interactions with different analytes, while wave function analysis elucidated the underlying intermolecular interactions. This work provides insights into the design of advanced mixed-mode stationary phases and the understanding of analyte-stationary phase interactions.
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