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Chemo-enzymatic Synthesis of N-glycans for Array Development and HIV Antibody Profiling
Published on: February 5, 2018
Structure and conformation of Hoffer's chlorosugar and the related β-azido and β-nitrile sugar
Luca Mensing1, Justin Landsmann1, Marcus Layh1
1Institute of Inorganic and Analytical Chemistry, University of Münster, Corrensstr. 28/30, Münster, 48149, Germany.
Abstract:
Hoffer's chlorosugar is an important, universal building block for the synthesis of nucleosides with artificial nucleobases, but its solid-state structure has remained undetermined. Herein we report on the single-crystal X-ray structure of Hoffer's chlorosugar, as well as the structural characterization of the related β-azido and β-nitrile sugars. Their crystal structures show similar intermolecular interactions and related supramolecular structures. Together, these structural elucidations and pseudorotational analyses close the longstanding gap in the characterization of important carbohydrate building blocks for the synthesis of artificial nucleosides.
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