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A Classification Algorithm for Diabetes Subtypes in a Swedish Cohort: Comparison With National Diabetes Register
Shobitha Vollmer1,2, Alice Maguolo1, Axel Lindström1,3
1Epigenetics and Diabetes Unit, Department of Clinical Sciences Malmö, Malmö, Sweden.
Article Highlights:
Diabetes subtype-specific research is challenging when using data from large registers, and validation studies of Swedish National Diabetes Register (NDR) diagnoses remain limited. We aimed to develop an algorithm to classify diabetes subtypes using linked longitudinal data, compare with NDR, and validate it using polygenic risk scores. We developed an algorithm that reliably distinguishes diabetes subtypes with higher granularity compared with NDR and is validated by polygenic risk scores. Our algorithm reveals clinically meaningful heterogeneity that may be overlooked in registers and enables subtype-specific diabetes research.
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