Myeloid-derived suppressor cells in hematologic malignancies: A current state of the field
Yulia Nefedova1, Dmitry I Gabrilovich2
1Ellen and Ronald Caplan Cancer Center, Wistar Institute, Philadelphia, PA, United States.
Abstract:
Myeloid-derived suppressor cells are a pivotal component of the immunosuppressive tumor microenvironment in hematologic malignancies. Through diverse mechanisms, they promote disease progression, therapeutic resistance, and immune evasion. This comprehensive review synthesizes current evidence on the roles of myeloid-derived suppressor cells across major hematologic cancers and evaluates their prognostic significance, highlighting implications for patient stratification and potential therapeutic targeting.
Related Concept Videos
Regulation of Hematopoietic Stem Cells
Differentiation of Common Myeloid Progenitor Cells
Multipotency of Hematopoietic Stem Cells
Mesenchymal Stem Cells
Bone Marrow Sampling and Transplants
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...


