Related Experiment Video
Updated: Oct 13, 2026
Photodynamic Therapy with Blended Conducting Polymer/Fullerene Nanoparticle Photosensitizers
Published on: October 28, 2015
Star-Chained Near-Infrared-Responsive Upconversion Nanoparticle/Fe-TCPP for Synergistic Photodynamic
Yu'e Hao1, Yuena Li1, Yu Chen1
1Hunan Key Laboratory of Typical Environment Pollution and Health Hazards, School of Public Health, Hengyang Medical School, University of South China, Hengyang421001, P. R. China.
Abstract:
In this study, a star-chained near-infrared responsive upconversion nanoparticle (UCNP)/Fe-TCPP nanocomposite (UFT) was fabricated via a two-step solvothermal method. Its phase, morphology, and structure were characterized using X-ray diffraction (XRD), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), and fourier transform infrared spectroscopy (FT-IR). Owing to electrostatic matching, UFT selectively targeted and killed Staphylococcus aureus. Under 980 nm irradiation at 1.0 W/cm2, 200 µg/mL UFT achieved a 98.46% bactericidal rate against 1 × 106 CFU/mL S. aureus within 18 min via a synergistic photodynamic/chemodynamic effect. In vivo wound healing experiments showed UFT promoted epidermal regeneration and accelerated wound repair. Radical trapping experiments coupled with electron spin resonance (ESR) spectroscopy identified superoxide anions (•O2-) and hydroxyl radicals (•OH) as the main reactive oxygen species involved in the process. These findings demonstrate that the as-prepared UFT nanocomposite exhibits both excellent near-infrared-responsive antibacterial performance and wound-healing efficacy, providing a promising experimental basis and theoretical foundation for the development of efficient photoresponsive antibacterial materials for the treatment of wounds infected with Gram-positive bacteria.
