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Updated: Oct 13, 2026

Frailty Assessment in an Aging Mouse Model
Published on: September 23, 2025
Modeling Human Frailty with a Smart Home-Based Approximation of Entropy
Katherine A Wuestney1, Beiyu Lin2, Diane J Cook3
1Washington State University, Vancouver, Washington, USA.
Abstract:
The global population is aging. These older adults face changes in health that result in increasing frailty. Digital biomarkers created by passive, continuous sensors offer an early indicator of impending frailty that can be used to delay or reverse frailty. Building on the notion of a human as a complex system, we introduce and compare three methods to model and estimate the complexity of indoor human behavior. Each method offers potential benefits for estimating human frailty. We introduce a formalization of the approaches, extend their use for arbitrary-size sensor suites, and demonstrate how they can be used to visualize and calculate a person's behavioral complexity based on smart home data collected continuously for an older adult subject.
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