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Updated: Oct 13, 2026

Line Shape Analysis of Dynamic NMR Spectra for Characterizing Coordination Sphere Rearrangements at a Chiral Rhenium Polyhydride Complex
Published on: July 27, 2022
Single-site substitution triggered supramolecular chirality inversion through cooperative H-bonding and π-π stacking
Sihan Liu1, Laiben Gao1, Xiaoqiu Dou1
1State Key Lab of Metal Matrix Composites, School of Materials Science and Engineering, Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, Shanghai Jiao Tong University, Shanghai 200240, China. gaolaiben@sjtu.edu.cn.
Abstract:
Herein, we report that single-site substitution in phenylalanine derivatives induces a twist of the π-π stacking between biphenyl cores together with a modulation of the H-bonding geometry. The cooperative H-bonding and π-π stacking ultimately trigger supramolecular chirality inversion. This work presents a new molecular strategy for tuning supramolecular chiral structures.
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