Related Experiment Video
Updated: Oct 13, 2026

Exploring Independent Effects of Follicle-Stimulating Hormone In Vivo in a Mouse Model
Published on: August 11, 2023
Should menopause care measure function? Functional Menopause as a testable research framework
Manuel Sánchez-Prieto1, Rafael Sánchez-Borrego2
1Department of Obstetrics and Gynecology, Dexeus Mujer, Hospital Universitari General de Catalunya, Sant Cugat del Vallès, Spain.
Abstract:
Contemporary menopause care increasingly recognises the multidimensional nature of midlife health, but it remains uncertain whether this broader perspective should include longitudinal measurement of functional capacity. We propose Functional Menopause as a testable framework for examining whether assessment of physical, cognitive, sexual, urogenital, and participation-related function provides clinically useful information beyond symptom burden and established risk assessment. Such an approach could identify adverse functional trajectories that are not captured by symptoms or biomarkers, but it could also medicalize normal ageing, misapply geriatric thresholds to midlife women, increase clinical burden, and widen inequities. Before routine implementation, prospective research should establish measurement properties, normative trajectories, prognostic validity, incremental clinical utility, feasibility, and clinical impact. Functional Menopause should therefore remain a research hypothesis rather than a screening recommendation or diagnostic construct.
Related Concept Videos
Menopause
Hormonal Regulation of the Menstrual Cycle
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH release.
The Menstrual Cycle
The menstrual phase occurs from days 1 to 5 and involves the shedding of the stratum functionalis, as a uterine...
Menses Phase
When fertilization does not occur, the corpus luteum deteriorates, causing a significant drop in the levels of estrogen and progesterone in the body. This hormonal decrease triggers the release of prostaglandins, which cause the uterine...
Hormonal Control of the Ovarian Cycle
Before puberty, the hypothalamus releases GnRH in a low frequency, low amplitude pulsatile manner. This along with the immature hypothalamic-pituitary-gonadal axis activity, results in low estrogen levels and the absence of a fully functional ovarian cycle. At puberty, GnRH secretion increases in both frequency and...
Hormonal Regulation
