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Does perturbed adaptive myelination contribute to cognitive dysfunction in Alzheimer's disease?
1Faculty of Medicine and Health Sciences, University of East Anglia, Norwich, United Kingdom.
Plos Biology
|October 12, 2026
Abstract:
The consequences of oligodendrocyte involvement in Alzheimer's disease are poorly understood. Could a key role of gray-matter oligodendrocytes-activity-dependent adaptive myelination to sustain changes in activity-be perturbed, leading to cognitive loss?