Related Experiment Video
Updated: Oct 14, 2026
Profiling Sensitivity to Targeted Therapies in EGFR-Mutant NSCLC Patient-Derived Organoids
Published on: November 22, 2021
Identifying interoceptive awareness profiles and potential intervention targets in patients with lung cancer
Xingliang Zhang1, Xueru Chen1, Jianxin Li1
1Wuxi School of Medicine, Jiangnan University, Wuxi, Jiangsu, China.
Purpose:
To identify latent profiles of self-reported interoceptive awareness among patients with lung cancer undergoing chemotherapy, compare network structures between these profiles, and explore potential dimensions of self-reported interoceptive awareness for future intervention research.
Methods:
A cross-sectional survey was conducted at a tertiary hospital in China from July 2025 to January 2026. Self-reported interoceptive awareness was assessed using the Multidimensional Assessment of Interoceptive Awareness (MAIA-2). Latent profile analysis, network analysis, and computer-simulated node perturbation analysis were used to identify interoceptive awareness subgroups, examine between-group network differences, and identify dimensions showing the greatest sensitivity to simulated perturbations.
Results:
Among 514 patients, two profiles were identified: a lower-level profile and a higher-level profile, with high classification accuracy (entropy = 0.937). Network structure differed significantly between the two profiles (p = 0.037), although global network strength did not. In the lower-level profile, Not-Worrying and Emotional Awareness showed greater centrality, with increases in Not-Worrying and decreases in Emotional Awareness yielding the greatest changes in simulation analyses. In the higher-level profile, Self-Regulation and Attention Regulation were central and also produced the largest simulated changes.
Conclusions:
Two latent profiles of self-reported interoceptive awareness were identified, with distinct network structures. The most central dimensions were Not-Worrying and Emotional Awareness in the lower-level profile and Self-Regulation and Attention Regulation in the higher-level profile, with perturbation-sensitive dimensions largely overlapping with these central dimensions within each profile. These exploratory findings suggest potential profile-specific dimensions for future research, but require prospective validation.
