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Parenchymal Calcification in Moyamoya Disease and Moyamoya Syndrome: Prevalence, Distribution
Saeko Irie1, Hideki Ogiwara2, Yoshiyuki Tsutsumi3
1Division of Neurology, National Center for Child Health and Development, Tokyo, Japan; Pediatric Epilepsy Center, National Center for Child Health and Development, Tokyo, Japan.
Background:
Parenchymal calcification is not a characteristic neuroradiologic manifestation of Moyamoya disease (MMD) or Moyamoya syndrome.
Objective:
To characterize the prevalence, distribution, and clinical course of parenchymal calcification in patients with MMD or Moyamoya syndrome.
Materials And Methods:
This single-center, retrospective cohort study was conducted between March 2002 and July 2023. Patients with a definitive diagnosis of MMD or Moyamoya syndrome were reviewed to identify those with parenchymal calcifications. Patient characteristics were determined based on established diagnostic criteria.
Results:
Among the 119 patients, pathological parenchymal calcifications were identified in 10 patients (8.5%). Five patients (4.2%) had no underlying predisposition to intracranial calcification.
Conclusions:
Parenchymal calcification occurred in a subset of patients with MMD, even in the absence of known predisposing conditions.