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Unlocking the secrets of naked mole-rat longevity
Yi-Xue Zhang1, Yu Chen1, Zhi-Yong Mao1
1Shanghai Key Laboratory of Maternal Fetal Medicine, Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, Frontier Science Center for Stem Cell Research, School of Life Sciences and Technology, Tongji University, Shanghai 200092, China.
Abstract:
Renowned for extreme longevity and extraordinary cancer resistance, the naked mole-rat ( Heterocephalus glaber) serves as a powerful biological model to uncover novel healthy aging mechanisms. Fourteen hallmarks have been proposed to describe the core features of biological aging; however, whether their direct enhancement contributes to longevity remains unclear. Here, we summarize current knowledge on the differential regulation of these aging hallmarks in the naked mole-rat and their potential roles in its exceptional lifespan. We also discuss current research limitations and suggest future directions to better elucidate the basis of naked mole-rat longevity, ultimately enabling the development of strategies to promote healthy aging in humans.
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