Related Experiment Videos
Beyond conventional treatments: cutting-edge strategies for ascites in cirrhosis
Weimiao Lin1, Wenjin Fan2, Lei Xu1
1Department of Gastroenterology, The First Affiliated Hospital of Ningbo University, Ningbo, China.
Abstract:
Ascites is a prevalent complication in cases of decompensated liver cirrhosis, having a considerable effect on the quality of life and prognosis of patients. Current treatment methods of ascites in cirrhosis primarily include conventional diuretics, paracentesis, albumin infusion, transjugular intrahepatic portosystemic shunt (TIPS), and liver transplantation. However, these approaches are associated with certain limitations and risks. In recent years, novel therapeutic strategies targeting distinct pathophysiological pathways of ascites have continued to emerge, including sodium-glucose cotransporter 2 (SGLT2) inhibitors, vasopressin analogues, regenerative medicine, and gut microbiota modulation. The present review focuses on emerging pharmacological strategies for ascites in cirrhosis, systematically summarizes their mechanisms of action, and discusses their efficacy, safety, and limitations, while also outlining future research directions.
Related Concept Videos
Ascites
Esophageal Varices-II: Clinical Features and Management
In the initial assessment, a thorough review of the patient's medical history is vital to identify risk factors such as liver disease, alcohol abuse, or...
Chronic Pancreatitis II: Collaborative Care
Assessment:
Heart Failure VI: Adjunct Therapies
Pleural Effusion II: Symptoms and Management
A pleural effusion is the abnormal collection of fluid between the parietal and visceral pleura layers of tissue that form the lining of the lungs and chest cavity. It can occur independently or due to surrounding parenchymal diseases, such as infection, malignancy, or inflammatory conditions.
Clinical Manifestations:
Varicose Veins II: Diagnostic Studies and Interprofessional Care